Patient Sh., female, born 1917. On November 3rd,
1975 she was operated on at the surgical department of the First
Tuberculosis Hospital of the city of Moscow by Cand. med. sci. A.V.
Doubrovskii for a mediastinal malignant tumour with metastases into
the both lungs. The x-ray examination revealed in the right side of
the chest an 8´13-cm massive intensive shadow adjacent to the shadow
of the mediastinum and diaphragm. On the outside of this formation
there are three round shadows up to 2 cm in size, located in the
lower and middle lobes of the lung. In the left lung, there are two
round shadows in the middle and lower pulmonary lobes, with a
diameter of up to 1.5-2 cm.
Because of the life-threatening clinical picture
of the compressed vena cava superior, the patient was subjected to
right-sided thoracotomy, revealing a gigantic tumour originating
from the middle lobe, intimally connected with the vena cava and
grown into the pericardium. Subpleurally there were determined large
dense formations with a diameter of up to 2 cm. The tumour was
removed, as well as a part of palpated dense neoplasms. Histological
study revealed the picture of squamous-cell carcinoma with elements
of necrosis. In the postoperative period, the round foci seen prior
to the operation remained in the left lung.
The IET (Immuno Embryo Therapy) commenced on November 25th, 1975 after immunologically revealing in the blood serum of the patient the
blocking factors in high concentration. Following a single injection
of placental preparations, patient Sh. showed in a month decreased
metastatic shadow on the left, and in three months the
roentgenological signs of metastases ceased to be revealed. 5 year
after the operation and immunoembryotherapy the case was described (V.I.
Govallo and A.V. Doubrovskii, 1981), and the patients were
demonstrated at the session of the thoracal section of the Moscow
Surgical Society. It was the first case where the pulmonological
surgeon was made sure of a possibility to remove the metastases
without chemotherapy (by the way, being of restricted efficacy in
this type of cancer). The histology of the preparations had to be
consulted twice, and the diagnosis remained unaltered. Patient Sh.
was followed-up for 8.5 years, with no pathology observed. In 1984
she died of cardiac attack, with the post-mortem examination
revealing no signs of cancer.
Figure 1. Roentgenogram of patient Sh. prior to surgery. Adjacent
to the right contour of the heart is an 8´13-cm large homogeneous
shadow with clear-cut contours. More laterally, there are three
round homogeneous foci with distinct edges, with a diameter of 1.5-2
cm (at the level of the anterior portions of ribs I, IV, and VII).
In the left lung, there are two similar foci at the level of
intercoastal spaces II and IV.
Figure 2. Three weeks after the operation and prior to IET. In
the lower lateral portion of the right lung there are massive
pleural over lapping, with two round foci remaining in the left
lung.
Figure 3. One month after IET. In the place of the metastatic
foci in the left lung, there is a considerably less in size shadow
at the level of intercoastal space IV. 4.5 years after the operation
and the IET, the round foci in the left lung are not detected. The
pulmonary picture is normal.
Case Report #2
Patient Sh., husband of the previous woman. He was
operated on the same day with his wife. The clinical-roentgenological
diagnosis: rapidly growing tumour of the lower lobe of the right
lung. The transthoracic puncture yielded the cells resembling
malignant ones. The patient was subjected to resection of the lower
and middle lobe of the right lung with enucleation of the lymph
nodes in the root of the lung, and in the mediastinum.
Histologically - squamous-cell carcinoma with elements of
decomposition.
The immunological examination performed on
November 25th, 1975 revealed high concentration of the blocking
factors in the blood serum, on the same day the IET was carried out.
Four months after, the blocking factor in blood was not detected. In
1976, the patient again developed coughing with sputum, presenting
infiltrative shadow in the upper lobe of the right lung. The patient
underwent antibacterial therapy and the repeated IET. Being a
citizen of the Ukraine, he then was examined, with no pathology
revealed, but after 1991, we received no data concerning him.
Case Report #3
Patient L., female, born in 1946. She was operated
on November 19th, 1980 for breast cancer, following surgery she
underwent several courses of chemotherapy (by the Couper technique),
in spite of these attempts, in 1981 she developed metastases into
the bone. The IET was begun on July 28th, 1981. Currently, she is
apparently healthy, able-bodied, presenting no complaints.
Case Report #4
Patient L-va, female, born in 1938, was operated
(bone resection) at the Kharkov Research Institute of Traumatology
and Orthopaedics in 1975 for chondrosarcoma of the right femur. The
IET was started in 1975, without any other treatment. Currently the
patient is alive, presenting no complaints.
Case Report #5
Patient T., male, born in 1929. In 1978, he was
operated on at the city of Kazan for right-sided pulmonary
carcinoma. The physicians suspected metastases into the mediastinum
and into the left lung. The patient refused the offered
chemotherapy. The IET was started on December 21st, 1978. Presently,
he works, having nothing to complain of.
Case Report #6
Patient P., male, born in 1936, was operated on
twice for malignant melanoma in the area of the left femur (on
December 23rd, 1989, and for the relapse thereof on April 29th,
1991), several courses of chemotherapy
were performed in the city of Lvov. The IET was started on November
20th, 1991, after which no relapses were noted. Currently, he is
apparently healthy, and able-bodied.
Case Report #7
Patient Sh., male, born in 1928. On January 2nd,
1992, he was operated on (by Professor V.B. Aleksandrov) for rectal
cancer. The IET commenced in the same year following radiotherapy.
Currently, the patient is able-bodied, presenting no complaints.
Case Report #8
Patient R., female. On September 4th, 1974 she
underwent resection at the Central Institute of Traumatology and
Orthopaedics (performed by Professor S.T. Zatsepin) according to the
Pirogov technique for synovial sarcoma of the right foot. IET
commenced from December 2nd, 1974. The patient developed neither
relapses, nor metastases. She emigrated
to Canada in 1991. Currently she is alive, presenting no complaints.
Case Report #9
Patient G., born in 1929. In 1986, he was operated
on for breast cancer (male). The surgical intervention was followed
by chemotherapy which the patient refused to continue. The IET was
started on December 9th, 1986. The patient is apparently healthy to
the present day.
Case Report #10
Patient B., female, born in 1954. Following
mastectomy and chemotherapy for breast cancer, a solitary metastasis
into the bones of the upper thoracic portion of the vertebral column
was revealed in 1995. It was supposed to be removed surgically, but
we decided to preliminarily perform the IET. Three months after,
positive dynamics was observed, with no operation needed. Currently,
roentgenological examination reveals no pathological alterations,
with the patient presenting no complaints whatsoever.
It seems currently difficult to speak of permanent
cure of the patients, even ten years after. Generally, in case of
cancer, even if complete remission in patients is noted for 10
years, we can speak of recovery as such only conditionally. For the
cause of the disease is not known, and is not removed completely. We
followed up two patients subjected to the IET, in whom remission
lasted 6 years (squamous-cell carcinoma of the lung) and 14 years
(renal carcinoma, hypernephroma), after which the patients rapidly
developed progressing complications (in the first case - a
mediastinal tumour, and in the second case - a metastatic lesion to
the liver). It bears evidence that the genetic prerequisites of
carcinogenesis preserve for a long time, and the tumour can acquire
resistance to any therapeutic modality.
It is also difficult to speak of statistics, since
our task was to study the immune status of oncological patients,
dynamics of the indices before and after treatment, working out of
an optimal and safe therapeutic regimen. Therefore, the IET was
carried out in a limited number of patients, the majority of
whom visited us at late stages of the
disease, after unsuccessful combined treatment. We abstained from
carrying out such treatment in patients with malignant lesions to
the blood system (and, consequently, the immunity system), and could
not attain remission in total metastatic involvement (stage 4) and
presence of metastases into the liver. Amongst the patients, those
who survived after IET with no manifestations of the disease for 10
years and more (patients with breast cancer, carcinoma of the lung,
womb, and other organs - stage IIA-III) amount to about 50 %. In
none of the cases we noted any short- or long-term complications of
the IET, which turned out inefficient, at the most.
The comparative ease and availability of the
suggested method, especially taking into consideration the current
economic condition of medicine, makes it possible to recommend
implementation thereof in oncological practice, not refusing the
commonly adopted methods of treatment. The combination with
radiotherapy might promote protection of the haemopoietic function,
however requiring to be specified. In cases, wherein the patients
were subjected to chemotherapy, we for two months undertook
nonspecific stimulation with various modulators of immunity, to be
followed by the IET.
Placenta (from Greek plakount - ''a pie, flat
cake'') is the most important organ of pregnancy, and a
multi-modality functional cunning gadget providing protection and
nourishment of the foetus. Being almost completely impermeable to
the white cells of the mother's blood, it serves as a filter for
immune cells and a plurality of antibodies, passing through only
those globulins which are indispensable for resistibility of the
infant-to-be. In the mammals, the external layer of the trophoblast
develops around the tiny embryo as early as on day 8-9 of its life.
Soon, it is divided into two layers, with the external layer forming
numerous villi which are implanted into the mucous membrane of the
uterus, wherein there is an already prepared bed stuffed with
immunosuppressor molecules, the mother's part of the placenta -
decidua.
The trophoblast is the so-called no-man's land,
bearing no proteins of tissular incompatibility, a unique in its
kind tissue. The matured placenta is known to consist of lobes
amounting to over 200 in number. On day 20 of gestation, the
placenta occupies about the half of the womb. Each of the numerous
villi bears the embryo's blood vessels whose total area gradually
reaches from 15 to 20 square metres. The nowhere-mixing blood flows
of the mother and foetus are divided with a thin plate through which
there takes place diffusion of oxygen, mineral and nutrient
substances. At the same time, the trophoblast actively generates
regulatory products, growth factors, and hormones, preparing the
mother's body to delivery and breast feeding. It is also the place
of location of multiple cellular ''factories'' producing the
blocking factors, activators of suppressor-lymphocytes, remote
tamers of immunity.
Extracts prepared from the tissues of the
trophoblast do not contain the series-A-and-B HLA antigens,
nor HLA-antibodies. At the same time,
they contain chorionic gonadotropin at a concentration of 3-5 IU/ml,
progesterone, (up to 3 mcg/g, IgA 15 - 20 mg/%, IgG (up to 500 mg/%,
IgM is absent.
A more sophisticated technology of manufacturing
the placental products consists in creation of hybridoma of cells of
the trophoblast at the peak of their functional activity (following
caesarean section), and myeloma cells. The purified preparations
obtained with this biotechnological method should be thoroughly
checked up, including also in interaction of the recipient's
lymphocytes with tumour proteins. Currently, such modification is
under the patent examination.
Further Case Studies:
Patient: Inna, female, date of
birth 6/26/69
Symptoms: 1998, liver pains,
weakness, chronic fatigue since 1996.
Condition: Sonogram showed in
1996: shading on liver, well defined, 7x12 cm.
Second sonogram in 1977 showed
growth to 8x13 cm . In 1998 biopsy proved
Adenocarcinoma.
Treatment in 1998: liver
cleansing, detoxification, 7 doses VG-1000.
Result: pain subsides, weakness
reduced.
Treatment in 1999: cleansing
and detoxification , 5 weeks VG-1000
at 2 doses per week.
Since 2001: Every month 3-5
doses.
Result: Woman’s condition has
improved to a point that now she lives normally.
Rectal touché and biopsy left
and right prostate lobe :positive. Gleason:3+3.
Refuses surgery ( radical
prostatectomy).
Treatment in 1997:
detoxification, Hulda Clark and Gerson therapy: PSA < 6.
In 1998: PSA >12. Start 50 drip
infusions Vit C, Taurine and Reduced Gluthation.
Takes food supplements : zinc,
genistein, selenium and lycopene.
Regular physical and blood
analyses proves no metastasis, PSA <8.
In 2001: frequent doses
Vg-1000.
In 2002: takes PC-Spes in high
doses. PSA drops to immeasurable values.
In 2003: urologist can not
detect any solid tissue in the prostate, bone and all others cans
Stay negative. Patient suffers
from side effects like gynaemasty, deep vein thrombosis and weight
gain, but reduce all treatment slowly in 2004 and lives normally.
Patient: Monique, female, born
1961.
Symptoms/diagnosis: In 1999:
uterus carcinoma grade III, stadium III plus metastasis.
Treatment : surgery removing
uterus sarcoma, no supplementary radiation.
Start Hulda Clark treatment, and
takes 7 gram Vit C , selenium, lactobacillus complex, Bioplacental
on a daily base.
In 2001 start Vg-1000 2 times a
week during 3 months, slowly reduced to2 injections per year. Her
surprised gynecologist confirms in 2003 : No signs of metastasis or
new tumors we control patient on low frequency 1 time per year.
